Endocrine Abstracts

Background: Effective management of adrenal insufficiency (AI) during sick day episodes requires adjusting oral glucocorticoid therapy or administering intramuscular injections to prevent adrenal crises. Given the critical nature of adrenal crisis management, educating families of young individuals with AI is essential.Aim: To critically appraise patient education concerning adrenal crisis management through a systematic...

Background: Effective management of adrenal insufficiency (AI) during sick day episodes involves adjusting oral glucocorticoid therapy or administering intramuscular injections to prevent adrenal crises. Therefore, educating families of young individuals with AI on emergency management is crucial.Aim: This study aims to critically evaluate online educational materials related to adrenal crisis management. We conducted a ...

Objectives: Delayed puberty is thought to be common in boys with Duchenne muscular dystrophy [DMD]. To date, studies addressing its frequency are not available. This study aims to report the frequency of delayed puberty in DMD from clinical examination.Methods: All boys with DMD aged at least 14 years in January 2022 known to the Glasgow paediatric neuromuscular service (2015-2022) were included. Thirty-seven boys were identified. All 37 boys had at leas...

Background: Recent studies show that Infliximab (IFX), an antibody against tumour necrosis factor α (TNFα), may improve growth in children with Crohn’s disease (CD). These studies have not adequately addressed the concomitant factors such as medication, nutrition and puberty that may also improve growth.Methods: Retrospective study of 22 children (13 M) with CD, median age at start of IFX 13.2 years (7.4, 16.1) with auxology at 6 months be...

Background: Growth retardation and pubertal delay is frequently encountered in children with inflammatory bowel disease (IBD). There are currently no published data on sitting height (SH), subischial leg length (SILL)and growth rates in relation to pubertal status in these children.Objective: To assess skeletal disproportion and growth rates in children with IBD.Methods: Retrospective study of 40 children (32M):35 Crohn’s dise...

Background: Recent studies show that infliximab (IFX), an antibody against tumour necrosis factorα (TNFα), may improve growth in children with Crohn’s disease (CD). These studies have not adequately addressed the concomitant factors such as medication, nutrition and puberty that may also improve growth.Methods: Retrospective study of 22 children (13M) with CD, median age at start of IFX 13.2 years (7.4, 16.1) with auxology at 6 months befo...

Background: Glucocorticoid (GC) therapy is standard of care of management of Duchenne Muscular Dystrophy (DMD) but its use is associated with a range of side-effects. Weight gain leading to significant obesity is common in GC-treated boys.Aim(s): To evaluate changes in growth parameters: height-SDS, weight-SDS, body mass index (BMI)-SDS following initiation of GC in DMD.Methods: Between 2013-2019, 26 boys with DMD were commenced on...

Introduction: There is a need to understand testicular development in adolescents with Duchenne Muscular Dystrophy (DMD).Objective: To evaluate testicular development and function in DMD over 12 months.Methods: All data are presented as median(range). 23 boys aged 12.4 years (10.0, 16.8) with a bone age delay of 0.9 years (−2.4, 7.1) had physical and biochemical assessment of puberty at Month 0(M0) and Month 12(M12) and divid...

Background: PPNAD is a rare form of bilateral adrenal hyperplasia associated with Carney complex and PRKAR1A mutation. We report the experience of monitoring disease activity in two patients with PPNAD.Both patients (case 1: a 7.4-year-old boy and case 2: a 6.1-year-old girl) presented with rapid onset of cushingoid symptoms, weight gain and hypertension together with multiple freckles and lentigines.Biochemical analysis on both pa...

Background: Although colonic polyps are associated with states of GH excess, no association with gastric polyps has been reported. We describe 2 patients who were treated with rhGH for non-GH deficient growth disorders and who were subsequently found to have gastric polyps.Patient 1: A girl aged 13.6 year with short stature was found to have Turner’s syndrome in the course of being investigated for abdominal pain, diarrhoea and rectal bleeding. Endo...